SONA Gold Nanorod-Induced Hyperthermia Enhances Immunogenic Response and Synergizes with IL-2 Immunotherapy to Reduce Tumor Size in Preclinical Models
Time: 12:00 pm
day: Conference Day 1
Details:
- SONA Gold Nanorods & Laser Hyperthermia: SONA’s gold nanorods induce localized tumor cell death through laser-induced hyperthermia, priming the immune system by exposing tumor antigens. This dual mechanism offers a potent strategy for cancer therapy
- Enhanced Immune Response: SONA’s gold nanorod-induced hyperthermia enhances immune response against tumors, increasing CD8+ T cell infiltration and promoting effector and memory subtype differentiation. Treatment also upregulates PD-1 expression on CD8+ T cells, suggesting potential for combination with immune checkpoint inhibitors
- Tumor Volume Reduction with Combined Therapy: Gold nanorod-induced hyperthermia, especially combined with IL-2 immunotherapy, significantly reduces tumor volume. Combination therapy led to decreased tumor volume at the injection site and abscopal effects, reducing distant, untreated tumors
