Nicolas Manel

Nicolas Manel

Company: Institut Curie

Job title: Co-Founder and Scientific Consultant, Stimunity; Director of Research at INSERM, Group Leader


Nicolas Manel is Director of Research at INSERM, Group Leader at Institut Curie ( and co-founder and scientific consultant at Stimunity ( Since 2010, his lab at Institut Curie is interested in the basic principles that operate at the intersection between innate immunity and viral replication, and their impact on adaptive immunity and cancer immunotherapy. His lab has discovered novel mechanisms of immune activation by viruses, including a Trojan horse mechanism of immune signal transmission by viral particles (Gentili et al., Science 2015) and the identification of NONO as an essential innate sensor of the HIV capsid in the nucleus (Lahaye et al., Cell 2018). In collaboration with Stimunity, his lab develops cGAMP-loaded Virus-Like Particles for cancer immunotherapy.


cGAMP-VLP: cGAMP-containing Virus-Like Particles, a biological platform to activate STING for cancer immunotherapy 11:05 am

Viruses with a lipid envelope transfer the natural STING agonist cGAMP between cells cGAMP-loaded Virus-Like Particles (cGAMP-VLP) efficiently deliver cGAMP to cells leading to STING activation cGAMP-VLP induce anti-tumor immunityRead more

day: Day Two

Speaker Q&A 11:30 am

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day: Day Two

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