Targeting the Innate Immune Checkpoint CD47-SIRPα Axis

Time: 11:50 am
day: Innate Immune Checkpoints & Activation Pre-Focus Day


  • The CD47-SIRPa axis suppresses macrophage phagocytosis and has emerged as an important innate immune checkpoint.
  • There are a number of agents targeting this pathway in clinical development, including antibodies, decoy receptors and bispecifics.
  • Emerging clinical data will be discussed.